57
5
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8708 |
Paroxetine
|
Serotonin Transporter | Neuroscience |
Paroxetine 是选择性血清素再摄取抑制剂,是苯基哌啶的衍生物。 它对于甲肾上腺素摄取抑制功能较弱,但比该位点其他SSRIs 更有效。 | |||
T22714 |
Decynium 22
|
Others | Others |
Decynium 22 是有机阳离子转运蛋白和单胺转运蛋白的抑制剂,具有抗抑郁作用。 | |||
T12232 |
Nitroxazepine
CIBA 2330Go |
Serotonin Transporter | Neuroscience |
Nitroxazepine (CIBA 2330Go) 是三环抗抑郁化合物,是一种 5-羟色胺去甲肾上腺素再摄取抑制剂,可用于抗抑郁的研究。 | |||
T22453 |
Venlafaxine
Wy 45030,文拉法辛 |
Serotonin Transporter | Neuroscience |
Venlafaxine (Wy 45030) 是一种口服有效的 5-羟色胺 (5-HT)/去甲肾上腺素 (NE) 重摄取的双重抑制剂,具有抗抑郁活性。 | |||
T11087 |
DOV-216,303 Free Base
DOV-216303 |
Dopamine Receptor; Serotonin Transporter; Norepinephrine | GPCR/G Protein; Neuroscience |
DOV-216,303 Free Base (DOV-216303) 是血清素、去甲肾上腺素和多巴胺再摄取的抑制剂,IC50 为 14、20 和 78 nM。 DOV-216,303 Free Base 具有抗抑郁作用。 | |||
T7061 |
Duloxetine
|
Serotonin Transporter | Neuroscience |
Duloxetine 是一种 5 羟色胺-去甲肾上腺素重吸收 (serotonin-norepinephrine reuptake) 抑制剂,Ki=4.6 nM,可作用于广泛性焦虑症的研究。 | |||
T10758L |
Centanafadine hydrochloride
EB-1020 hydrochloride |
Dopamine Receptor; Serotonin Transporter; Adrenergic Receptor; Norepinephrine | GPCR/G Protein; Neuroscience |
Centanafadine hydrochloride (EB-1020 hydrochloride) 是一种去甲肾上腺素(NE)/多巴胺(DA)转运的双抑制剂,还能抑制5-羟色胺(serotonin)转运体。它对人 NE,DA 和5-羟色胺转运体的 IC50值分别为6 nM,38 nM 和 83 nM。 | |||
T3526 |
Dasotraline hydrochloride
SEP-225289 hydrochloride,达索曲林盐酸盐 |
Dopamine Receptor; 5-HT Receptor; Serotonin Transporter; Norepinephrine | GPCR/G Protein; Neuroscience |
Dasotraline hydrochloride (SEP-225289 hydrochloride) 是具有阻断多巴胺 (IC50=4 nM),去甲肾上腺素 (IC50=6 nM) 和三羟色胺转运蛋白 (IC50=11 nM)的三重再摄取抑制剂。 | |||
T0450 |
Fluoxetine
氟西汀,LY-110140 |
5-HT Receptor; Serotonin Transporter; MRP; Autophagy | Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Fluoxetine (LY-110140) 是一种高度特异性的血清素摄取抑制剂,是选择性 5-羟色胺 (5-HT) 再吸收抑制剂。Fluoxetine 具有抗抑郁活性。 | |||
T2395 |
Vortioxetine
沃替西汀,Lu AA 21004 |
5-HT Receptor; Serotonin Transporter | GPCR/G Protein; Neuroscience |
Vortioxetine (Lu AA 21004) 是5-HT1A、5-HT1B、5-HT3A、5-HT7受体和 5-羟色胺转运体抑制剂,Ki 值分别为 15、33、3.7、19 和 1.6 nM。它作为抗抑郁药,用于治疗重度抑郁症。 | |||
T1279 |
Vilazodone
维拉佐酮,SB659746A,EMD 68843 |
5-HT Receptor; Serotonin Transporter | GPCR/G Protein; Neuroscience |
Vilazodone (SB659746A) 是一种可口服的选择性 5 -羟色胺再摄取抑制剂 (SSRI) 和部分5-HT1A 受体激动剂。它有抗抑郁作用,可用于抑郁症和情绪性疾病的研究。 | |||
T1189 |
Milnacipran hydrochloride
盐酸米那普仑,Milnacipran HCl,Savella,Dalcipran |
Serotonin Transporter; Norepinephrine | Neuroscience |
Milnacipran hydrochloride (Savella) 是一种5-羟色胺-去甲肾上腺素重吸收抑制剂(SNRI),可用于纤维肌痛的研究。 | |||
T2594 |
Dextromilnacipran
Levomilnacipran,左旋米那普仑 |
Serotonin Transporter; Norepinephrine | Neuroscience |
Dextromilnacipran (Levomilnacipran) 是米那普仑的对映体,是一种选择性 5- 羟色胺和去甲肾上腺素(5-HT/NE)再摄取抑制剂,也是一种人类 α 肾上腺素能受体拮抗剂,IC50=3.4 μM。 | |||
T0472 |
Venlafaxine hydrochloride
Venlafaxine HCl,盐酸文拉法辛,Wy 45030 hydrochloride |
5-HT Receptor; Serotonin Transporter | GPCR/G Protein; Neuroscience |
Venlafaxine hydrochloride (Wy 45030 hydrochloride) 是一种口服有效的 5-羟色胺 (5-HT)/去甲肾上腺素 (NE) 重摄取的双重抑制剂,具有抗抑郁活性。 | |||
T6232 |
Vilazodone Hydrochloride
盐酸维拉佐酮,SB659746A,EMD 68843,Vilazodone HCl |
Others; 5-HT Receptor; Serotonin Transporter | GPCR/G Protein; Neuroscience; Others |
Vilazodone Hydrochloride (EMD 68843) 是 5-HT1A 受体和特异性 5-羟色胺再摄取抑制剂(SSRI) 的部分激动剂,用于治疗重度抑郁症。 | |||
T2092 |
Amitifadine hydrochloride
DOV-21947 hydrochloride,EB-1010 hydrochloride |
Dopamine Receptor; 5-HT Receptor; Serotonin Transporter; Norepinephrine | GPCR/G Protein; Neuroscience |
Amitifadine hydrochloride (EB-1010 hydrochloride) 是一种 5-羟色胺-去甲肾上腺素-多巴胺的再摄取抑制剂(SNDRI),其在 HEK 293 细胞中测得的 IC50值分别为 12, 23, 96 nM。 | |||
T0450L |
Fluoxetine hydrochloride
Fluoxetine HCl,盐酸氟西汀,LY-110140,Lilly110140 |
5-HT Receptor; Serotonin Transporter; Autophagy | Autophagy; GPCR/G Protein; Neuroscience |
Fluoxetine hydrochloride (Lilly110140) 是一种高度特异性血清素摄取抑制剂。它被用作抗抑郁药,并且通常比传统的抗抑郁药具有更可接受的副作用特征。 | |||
T7940 |
Milnacipran ((1S-cis) hydrochloride)
左旋米那普林,Levomilnacipran Hydrochloride |
Serotonin Transporter | Neuroscience |
Milnacipran (1S-cis) hydrochloride (Levomilnacipran Hydrochloride) 是 5-羟色胺去甲肾上腺素再摄取抑制剂,用于研究纤维肌痛。 | |||
T0482 |
Sertraline hydrochloride
Sertraline HCl,CP-51974-1 HCl,盐酸舍曲林 |
5-HT Receptor; Serotonin Transporter | GPCR/G Protein; Neuroscience |
Sertraline hydrochloride (Sertraline HCl) 是选择性 5- 羟色胺再吸收抑制剂类的抗抑郁剂,可用于多种疾病的研究,如重度抑郁症和强迫症。 | |||
T6461 |
Dapoxetine hydrochloride
LY-210448,LY-210448 hydrochloride,Dapoxetine HCl,盐酸达泊西汀,Priligy |
5-HT Receptor; Serotonin Transporter | GPCR/G Protein; Neuroscience |
Dapoxetine hydrochloride (LY-210448 hydrochloride) 是一种具有口服活性的、选择性的血清素再摄取 (serotonin reuptake) 抑制剂 (SSRI),可用于研究早泄 (PE) 。 | |||
T0991 |
Desipramine hydrochloride
NSC-114901,Desmethylimipramine,盐酸去甲咪嗪,JB-8181,EX-4355,Norimipramine,G-35020 |
Dopamine Receptor; 5-HT Receptor; Serotonin Transporter; Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Desipramine hydrochloride (Norimipramine) 是一种二苯并氮杂类衍生物三环类抗抑郁药,可作为选择性去甲肾上腺素再摄取抑制剂。 它还显示出较弱的 5-羟色胺再摄取抑制、α1 阻断、抗组胺和抗胆碱能作用。 | |||
T7941 |
Imipramine hydrochloride
盐酸丙咪嗪,Imipramine (hydrochloride),Tofranil,G 22355,Imipramine HCl,Melipramine |
Serotonin Transporter | Neuroscience |
Imipramine hydrochloride (Imipramine HCl) 可抑制血清素转运蛋白,IC50=32 nM。它可阻止胰酶的易位,阻碍 MV 和外泌体的分泌。 | |||
T6493 |
Escitalopram Oxalate
草酸右旋西酞普兰,依他普仑草酸盐,Cipralex,(S)-(+)Citalopram oxalate |
Others; 5-HT Receptor; Serotonin Transporter | GPCR/G Protein; Neuroscience; Others |
Escitalopram Oxalate ((S)-(+)Citalopram oxalate) 是一种外消旋 Citalopram 的 S-对映体,是一种选择性 5-羟色胺再摄取抑制剂,Ki=0.89 nM,比 R(-)-enantiomer 结合亲和力高 30 倍。它对多巴胺转运体和去甲肾上腺素转运体均有选择性,是一种研究抑郁症的抗抑郁药。 | |||
T0678 |
Amitriptyline hydrochloride
Amitriptyline HCl,Tryptizol,盐酸阿米替林,Domical,Annoyltin |
Trk receptor; Sigma receptor; 5-HT Receptor; Serotonin Transporter; Sodium Channel; Adrenergic Receptor; AChR; Norepinephrine; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience; Tyrosine Kinase/Adaptors |
Amitriptyline hydrochloride (Annoyltin) 是血清素再摄取转运体和去甲肾上腺素再摄取转运体抑制剂,还与多巴胺再摄取转运体结合,其Ki 为 2.58 μM。它也抑制肾上腺素能受体、毒蕈碱受体、组胺受体、5-羟色胺受体。它是TrkA 和TrkA 受体的激动剂,具有强神经营养活性和有抗抑郁作用。 | |||
T2395L |
Vortioxetine hydrobromide
氢溴酸沃替西汀,Vortioxetine (Lu AA21004) HBr,Vortioxetine HBr,盐酸沃替西汀,Lu AA21004 hydrobromide |
5-HT Receptor; Serotonin Transporter | GPCR/G Protein; Neuroscience |
Vortioxetine hydrobromide (Lu AA21004 hydrobromide) 是5-HT1A、5-HT1B、5-HT3A、5-HT7受体和5-羟色胺转运体(SERT)的抑制剂,Ki 值分别为 15、33、3.7、19 和 1.6 nM。 | |||
T1077 |
Fluvoxamine maleate
氟伏沙明马来酸盐,马来酸氟伏沙明,MK-264,DU-23000 (maleate) |
5-HT Receptor; Serotonin Transporter | GPCR/G Protein; Neuroscience |
Fluvoxamine maleate (DU-23000 (maleate)) 是一种5-羟色胺再吸收抑制剂,有抗抑郁作用。 | |||
T0255 |
Clomipramine hydrochloride
Clomipramine HCl,Anafranil,盐酸氯米帕明 |
Dopamine Receptor; 5-HT Receptor; Serotonin Transporter; Norepinephrine; GST | GPCR/G Protein; Neuroscience; oxidation-reduction |
Clomipramine hydrochloride (Anafranil) 是一种5-羟色胺转运体(Ki:0.14 nM)、去甲肾上腺素转运体(Ki:54 nM)和多巴胺转运体(Ki:3 nM)阻断剂。 | |||
T1483 |
Citalopram hydrobromide
Lu 10-171,Nitalapram HBr,Bonitrile HBr,XU-62-320,Lu 10-171 HBr,氢溴酸西酞普兰,Citalopram HBr |
5-HT Receptor; Serotonin Transporter; Autophagy | Autophagy; GPCR/G Protein; Neuroscience |
Citalopram hydrobromide (XU-62-320) 是一种选择性 5-羟色胺再摄取抑制剂,可选择性地抑制 CNS 神经元对 5-羟色胺的再摄取,从而增强中枢神经系统中的 5-羟色胺能活性,也具有抗抑郁活性。它抑制兔血小板中 5-HT 的摄取,IC50为 14 nM。 | |||
T1636 |
Paroxetine hydrochloride
Paroxetine HCl,BRL29060 hydrochloride,FG-7051,BRL29060A,盐酸帕罗西汀 |
5-HT Receptor; Serotonin Transporter; GRK; AChR; Autophagy | Autophagy; GPCR/G Protein; Neuroscience |
Paroxetine hydrochloride (Paroxetine HCl) 是一种血清素摄取抑制剂,能抑制 GRK2 活性,IC50值为 14 μM。它可研究抑郁症。 | |||
T21013 |
Clomipramine
Chlorimipramine,Anafranil,Clomicalm,Anafranil (free base),Clomipramina,氯米帕明 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Clomipramine (Clomicalm) 是一种三环类抗抑郁药,能够有效阻断 5-HT 再摄取 (IC50:1.5 nM) ,可用于研究强迫症 (OCD) 及抑郁症。 | |||
T6188 |
Desvenlafaxine succinate hydrate
O-Desmethylvenlafaxine succinate hydrate,WY 45233 Succinate,琥珀酸去甲文拉法辛,Desvenlafaxine Succinate |
5-HT Receptor; Serotonin Transporter; Norepinephrine | GPCR/G Protein; Neuroscience |
Desvenlafaxine succinate hydrate (WY 45233 Succinate) 是 Venlafaxine 主要代谢物的丁二酸盐形式,在人多巴胺转运体上显示弱的结合亲和力。它是具有口服活性的、能透过血脑屏障的5-HT 和 去甲肾上腺素再摄取的抑制剂,对 hSERT 和 hNET 的IC50值分别为47.3 nM 和531.3 nM。 | |||
T3275 |
Nefazodone hydrochloride
Dutonin,MJ-13754-1,Serzone,BMY-13754-1,BMY-13754,萘法唑酮盐酸盐 |
5-HT Receptor; Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Nefazodone hydrochloride (Serzone) 是一种强效和选择性的5HT2A 拮抗剂,Ki 为5.8 nM,对 5-HT 和去甲肾上腺素摄取具有中度抑制作用,IC50分别为 290 和 300 nM。它是一种苯哌嗪类抗抑郁药,具有微弱的 α-肾上腺素阻断活性,用于治疗抑郁症、攻击性行为和恐慌症。 | |||
T1471 |
Duloxetine hydrochloride
Duloxetine HCl,盐酸度洛西汀,LY-248686 hydrochloride,(S)-Duloxetine hydrochloride,LY-248686 HCl |
Dopamine Receptor; 5-HT Receptor; Serotonin Transporter; Norepinephrine | GPCR/G Protein; Neuroscience |
Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) 是一种 5-羟色胺-去甲肾上腺素重吸收 (serotonin-norepinephrine reuptake) 抑制剂 (SNRI),Ki=4.6 nM,可用于广泛性焦虑症的研究。 | |||
T0039 |
Dapoxetine
达波西汀,Dapoxetina,Dapoxetinum |
Others; 5-HT Receptor | GPCR/G Protein; Neuroscience; Others |
Dapoxetine (Dapoxetina) 是一种选择性5-羟色胺再摄取抑制剂,用于治疗早泄。 | |||
T1580 |
Desvenlafaxine
去甲文拉法辛,WY 45233 Succinate,O-Desmethylvenlafaxine |
5-HT Receptor; Serotonin Transporter; Norepinephrine | GPCR/G Protein; Neuroscience |
Desvenlafaxine (O-Desmethylvenlafaxine) 是 Venlafaxine 主要代谢物的丁二酸盐形式,在人多巴胺转运体上显示弱的结合亲和力。它是一种具有口服活性的、能透过血脑屏障的5-HT 和去甲肾上腺素再摄取的抑制剂,对 hSERT 和 hNET 的IC50值分别为 47.3 nM 和 531.3 nM。 | |||
T9395 |
(1S,4R)-N-Desmethyl Sertraline Hydrochloride
|
Others | Others |
(1S,4R)-N-DesmethylSertralineHydrochloride 是一种Serotonin transporter 和 Norepinephrine transporter 抑制剂,IC5分别为19 nM 和35 nM. | |||
T9833 |
Opiranserin hydrochloride
|
P2X Receptor; GlyT; 5-HT Receptor | GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience |
Opiranserin hydrochloride 是甘氨酸转运蛋白 2 型 (GlyT2) 和 5-羟色胺受体 2A (5HT2A) 的双重拮抗剂,IC50 分别为 0.86 和 1.3 μM。它显示对 rP2X3 的拮抗活性 (IC50=0.87 μM)。它正在开发为用于治疗术后疼痛的注射剂。 | |||
T9169 |
MPP+ iodide
|
Mitochondrial Metabolism; Autophagy | Autophagy; Metabolism |
MPP+ iodide 是一种 5-羟色胺转运体的高亲和力底物,也是一种神经毒素 MPTP 的有毒代谢物,通过选择性破坏黑质多巴胺能神经元,在动物模型中引起帕金森病症状。它被多巴胺转运体吸收进入多巴胺能神经元,通过影响呼吸链复合体 I 对线粒体发挥神经毒性作用。 | |||
T64317 |
ZZL-7
|
Serotonin Transporter | Neuroscience |
ZZL-7是一种起效快的抗抑郁药。ZZL-7破坏中缝背核(DRN)神经元一氧化氮合酶(nNOS)和血清素转运蛋白(SERT)之间的相互作用。ZZL-7可以很容易地穿过血脑屏障。ZZL-7在重度抑郁症(MDD)中具有研究价值。 | |||
T41194 |
FFN 102 mesylate
|
Others | Others |
FFN 102 mesylate 是pH 响应型荧光假神经递质(FFN),作为选择性多巴胺转运蛋白(DAT)和VMAT2底物。FFN 102 mesylate 与38个中枢神经系统受体(包括多巴胺和血清素受体)无明显结合。它的Ex-max在pH 值5时为340 nm,在pH 值7.5时为370 nm,在pH 值为5和7.5时,Em-max为435 nm。 | |||
T10758 |
Centanafadine
EB-1020 |
Others | Others |
Centanafadine is a dual inhibitor of norepinephrine (NE)/dopamine (DA) transporter, also inhibits serotonin transporter (IC50s: 6 nM, 38 nM, and 83 nM for human NE, DA, and serotonin transporter). | |||
T31791 |
FFN246 HCl
FFN 246,FFN246 hydrochloride,FFN246,FFN-246 |
||
FFN246 is a fluorescent substrate for both the serotonin transporter and the vesicular monoamine transporter 2 (VMAT2). | |||
T23629 |
Adam I-123
Adam I 123,Adam I123 |
||
Adam I-123 is a radiopharmaceutical containing the serotonin transporter (SERT) ligand, with SERT-binding and radioisotope activities. SERT is a monoamine transporter protein found in the membranes of neurons and platelets. | |||
T27689 |
JNJ-7925476 HCl
JNJ-7925476,JNJ7925476,JNJ 7925476 |
||
JNJ-7925476 HCl is a triple monoamine uptake inhibitor. JNJ-7925476 Salt blocks the dopamine transporter (DAT), norepinephrine transporter (NET) and serotonin transporter (SERT) in the central nervous system. The ED(50) values for JNJ-7925476 occupancy of | |||
T10842 |
Clomipramine D3
氯米帕明 D3 |
Others | Others |
Clomipramine D3 is the deuterium-labeled Clomipramine. Clomipramine is a serotonin transporter, norepinephrine transporter dopamine transporter blocker (Ki: 0.14, 54 and 3 nM). | |||
T10842L |
Clomipramine D3 hydrochloride
|
Others | Others |
Clomipramine D3 hydrochloride is the deuterium-labeled Clomipramine. Clomipramine is a serotonin transporter, norepinephrine transporter dopamine transporter blocker (Ki: 0.14, 54 and 3 nM). | |||
T35087 |
VVZ-149
VVZ 149 |
||
VVZ-149 is an antagonist of both serotonin receptor 2A (5HT2A) and glycine transporter type 2 (GlyT2), with potential anti-nociceptive activity. | |||
T78684 |
FFN246
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
FFN246作为serotonin transporter (SERT) 和 vesicular monoamine transporter2 (VMAT2) 的荧光双底物探针,具有392/427 nm的激发和发射光谱。该化合物能够通过SERT依赖性积累,标记小鼠脑组织中的5-羟色胺能神经元。 | |||
T70615 | TAS-303 | ||
TAS-303 is a selective norepinephrine reuptake inhibitor which displays significant norepinephrine transporter (NET) inhibitory activity toward serotonin or dopamine transporters. Radioligand-binding studies showed that TAS-303 selectively and potently inhibited [3H]norepinephrine binding to the human NET. | |||
T71772 |
Bicifadine free base
|
||
Bicifadine, also known as DOV-220075, CL 220,075, is a SNDR inhibitor potentially for the treatment of lower back pain. Bicifadine has a non-opioid, non-NSAID mechanism for the treatment of pain, which should have less abuse potential than opioid drugs and less propensity to cause gastric ulcers than NSAID drugs. While the drug is purported to be a serotonin (SERT) and noradrenaline transporter (NET) inhibitor, it also has effects at the dopamine transporter (DAT), effectively making it a broad... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7521 |
Azaphen
Pipofezin hydrochloride,阿扎吩,Pipofezine hydrochloride,Azafen |
5-HT Receptor; Serotonin Transporter | GPCR/G Protein; Neuroscience |
Azaphen (Pipofezin hydrochloride) 是一种 5-羟色胺重吸收抑制剂。 | |||
T1317 |
Cinchonidine
奎宁树,α-Quinidine,辛可尼丁,L-Cinchonidine |
5-HT Receptor; Serotonin Transporter; Parasite | GPCR/G Protein; Microbiology/Virology; Neuroscience |
Cinchonidine (L-Cinchonidine) 是在金鸡纳和角蒿中发现的一种生物碱,有抗疟活性。 它是用于有机化学中不对称合成的砌块,是血清素转运蛋白的弱抑制剂。 | |||
T0185 |
Escitalopram
Seroplex,依他普仑,S-(+)-Citalopram,艾司西酞普兰,(S)-Citalopram |
Dopamine Receptor; 5-HT Receptor; Serotonin Transporter; Adrenergic Receptor; AChR; Norepinephrine; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Escitalopram (Seroplex) 是一种外消旋 Citalopram 的 S-对映体,是一种选择性 5-羟色胺再摄取抑制剂,Ki=0.89 nM,比 R(-)-enantiomer 结合亲和力高 30 倍。它对多巴胺转运体和去甲肾上腺素转运体均有选择性,是一种研究抑郁症的抗抑郁药。 | |||
T19772 |
Mesembrenone
(+)-Mesembrenone |
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Mesembrenone is a selective the serotonin transporter (SERT) inhibitor. Mesembrenone is the main alkaloid of Sceletium tortuosum. | |||
T75436 | Jatrorrhizine hydroxide | ||
Jatrorrhizine hydroxide, 一种从黄连中提取的生物碱,展现了神经保护、抗菌、抗疟原虫及抗氧化的活性。作为一种高效的乙酰胆碱酯酶(AChE)抑制剂(IC50=872 nM),其对BuChE的选择性高达115倍。此外,Jatrorrhizine hydroxide还能通过抑制uptake-2 transporter活性来减少血清素(5-HT)和去甲肾上腺素(NE)的摄取,表现出口服活性。 |